Buy Glipita M 50/500 (Sitagliptin 50mg+Metformin 500mg) 30’s Online Now in Nairobi, Kenya – Effective Type 2 Diabetes Control
Glipita M 50/500 (Sitagliptin 50mg+Metformin 500mg) 30’s is a clinically proven combination medication designed for precise blood sugar management in adults with type 2 diabetes mellitus. Developed to work synergistically, this tablet not only helps control hyperglycemia but also aids in preventing long‐term diabetes complications. Its dual action makes it an ideal choice for patients who require additional glycemic control alongside diet and exercise.
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Product Overview
Glipita M 50/500 is a fixed-dose combination tablet that merges two powerful antihyperglycemic agents: sitagliptin and metformin hydrochloride. Sitagliptin belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors, which enhance the activity of incretin hormones. Metformin, a member of the biguanide class, works primarily by reducing hepatic glucose production and improving peripheral insulin sensitivity. This complementary mechanism of action offers a comprehensive approach to lowering both fasting and postprandial blood sugar levels.
Key Benefits:
- Provides effective glycemic control
- Supports weight neutrality or modest weight loss
- Reduces the risk of diabetes complications such as kidney damage and cardiovascular events
- Suitable as monotherapy or in combination with other diabetes medications
Mechanism of Action
Sitagliptin
Sitagliptin functions by inhibiting the DPP-4 enzyme. This inhibition prevents the breakdown of incretin hormones—glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). When these hormones remain active longer, they stimulate pancreatic beta cells to increase insulin secretion in a glucose-dependent manner and simultaneously reduce glucagon release from alpha cells. As a result, hepatic glucose production is lowered, contributing to improved overall glycemic control.
Metformin
Metformin reduces blood sugar levels by decreasing liver glucose production (gluconeogenesis) and improving insulin sensitivity in muscle tissue. By enhancing peripheral glucose uptake and delaying intestinal glucose absorption, metformin works to lower both basal and postprandial plasma glucose without causing hypoglycemia when used as monotherapy. This makes it a reliable partner to sitagliptin in the management of type 2 diabetes.
Dosage & Administration
The recommended dosage is individualized based on the patient’s current regimen, effectiveness, and tolerability. Glipita M 50/500 is generally administered twice daily with meals to reduce gastrointestinal side effects associated with metformin. The standard starting dose for patients not previously on metformin is one tablet (50mg sitagliptin/500mg metformin) taken twice daily. For patients already on metformin therapy, the dose of sitagliptin is adjusted to 50mg twice daily (totaling 100mg per day) while maintaining the existing metformin dose. In cases where metformin is dosed at 850mg twice daily, the combination is adjusted to one tablet containing 50mg sitagliptin and 1000mg metformin hydrochloride twice daily.
Patients should adhere to their prescribed schedule and not discontinue use without consulting a healthcare provider. For those using an extended-release formulation, the tablet is taken once daily with a meal—preferably in the evening—to maximize tolerability and adherence.
Precautions & Side Effects
While Glipita M 50/500 is effective, it is important to consider the following precautions:
- Contraindications: Not suitable for patients with significant renal dysfunction (serum creatinine levels ≥1.5 mg/dL for males or ≥1.4 mg/dL for females), metabolic acidosis, or a history of severe hypersensitivity reactions (e.g., anaphylaxis or angioedema) to sitagliptin or metformin.
- Side Effects: Common adverse reactions may include diarrhea, nausea, vomiting, upset stomach, headache, and sore throat. When used in combination with insulin or sulfonylureas, there is an increased risk of hypoglycemia. In rare cases, lactic acidosis may occur, particularly in patients with conditions that predispose them to renal or hepatic impairment.
- Monitoring: Regular monitoring of kidney function, liver enzymes, and vitamin B12 levels is recommended during long-term therapy.
- Drug Interactions: Caution is advised when Glipita M 50/500 is co-administered with medications that affect renal function or alter glycemic control, such as ACE inhibitors, cimetidine, or iodinated contrast agents.
Additional Benefits & Usage Tips
Glipita M 50/500 not only helps control blood sugar levels but also supports an overall diabetes management plan. Here are some practical tips for optimal use:
- Consistency: Take the medication at the same time every day, ideally with meals, to maximize absorption and minimize gastrointestinal discomfort.
- Lifestyle Integration: Combine medication use with a healthy diet and regular physical activity to enhance glycemic control.
- Communication: Inform your doctor about all current medications and any underlying conditions, especially kidney or liver issues.
- Emergency Response: Recognize signs of hypoglycemia (such as shakiness, sweating, or confusion) and seek immediate assistance if they occur.
Storage & Handling
Store Glipita M 50/500 in a cool, dry place below 25°C and away from direct light. Keep the medication out of reach of children and always check the expiry date before use.
Frequently Asked Questions (FAQs)
Q: What is Glipita M 50/500 used for?
A: Glipita M 50/500 is used to manage type 2 diabetes mellitus by controlling high blood sugar levels through the complementary action of sitagliptin and metformin.
Q: How should I take Glipita M 50/500?
A: The tablet should be taken twice daily with meals. Patients not previously on metformin start with one tablet (50mg sitagliptin/500mg metformin) twice daily, while those already on metformin maintain their dose with an added 50mg of sitagliptin twice daily.
Q: What are the common side effects of Glipita M 50/500?
A: Common side effects include diarrhea, nausea, vomiting, upset stomach, headache, and sore throat. There is also a risk of hypoglycemia when used with other diabetes medications such as insulin or sulfonylureas.
Q: Can Glipita M 50/500 be used with other diabetes medications?
A: Yes, it can be prescribed as monotherapy or in combination with other antidiabetic drugs. However, when used with insulin or sulfonylureas, dose adjustments may be necessary to reduce the risk of hypoglycemia.
Q: Is Glipita M 50/500 safe for everyone?
A: It is not recommended for patients with significant renal or hepatic impairment or those with a history of severe allergic reactions to its components. Always consult your doctor before starting this medication.
Q: Where can I buy Glipita M 50/500 (Sitagliptin 50 mg + Metformin 500mg) 30’s in Kenya?
A: You can buy Glipita M 50/500 (Sitagliptin 50mg+Metformin 500mg) 30’s now online in Kenya, Nairobi, Muthaiga, Gigiri, Runda, Karen, Kileleshwa, Kilimani, Westlands, Parklands, Nakuru, Mombasa, Diani, Kitale, Eldoret, Kisumu, Kiambu, Thika, Ruiru, Ruaka, Kikuyu, Juja, Ngong, Nyahururu, Nanyuki, Lamu, Malindi, Kajiado, Machakos, Embu, Nyeri, Murang’a, Meru, Juba (South Sudan), Kigali, Kampala, and across East Africa from HealthAlone, or visit our physical shop at Kahawa Sukari Shopping Center, Nairobi.
